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Home » Partner search » NewPas New methods of Patient stratification for personalized therapeutic solutions.

NewPas New methods of Patient stratification for personalized therapeutic solutions.

PROJECT OVERVIEW
PS ID: 

PS-IL-101558

Status: 

Closed


PROJECT DESCRIPTION
Proposal Outline: 

HORIZON 2020 Health, demographic change and well-being

SC1-PM-02-2017: New concepts in patient stratification

(RIA) 40.0     04 Oct 2016 (First stage) 11 Apr 2017 (Second stage)

Specific Challenge: Despite the major advances in understanding disease in the post-genomic era, still a majority of all drugs are effective in only a limited number of patients. From a clinical perspective, implementing knowledge-based decisions on what therapeutics to use for which patients and, if relevant, in which combinations, are extremely challenging. The aspiration to provide more effective therapeutic interventions tailored to the individual or groups of individuals with common molecular phenotypes remains unfulfilled because of the variable response of individuals to such interventions. 

 

The proposed project will research and deliver new methods for disease-mechanism based patient stratification to address the needs for stratified or personalized therapeutic interventions. The proposals will develop new methods and implement them by integrated software system that will provide solutions to analyze multidimensional and longitudinal data from multiple sources, using areas like pharmacogenomics, systems biomedicine, big data analysis and computational modeling.

The new methods will support the development of improved targeted therapies, optimizing the intervention to individual patients, thus facilitating achievement of a greater success in treating or curing the patients.

The system and the process that will demonstrate new concepts of stratification will be validated in pre-clinical and clinical studies in 3 different locations, taking into account sex and gender differences. The system will be focused on addressing 3 complex diseases having high prevalence and possibly will also have high economic impact.

In the case of success system can in future be gradually improved by SMEs participated in the project by future developments to address main complex diseases.

The system design and implementation will comply with the regulatory aspects needed for clinical practice. The companies and SMEs participated in the system development will benefit from detailed plans for commercialization opportunities. 

Keywords: 
medical
Complex diseases
patient stratification
diseases
therapies
targeted therapies
phenotypes


PARTNER PROFILE SOUGHT
Required skills and Expertise: 

Hospital/University/company 

1. Expirienced in coordination and management of concortium

2. Expert in proposal writing

 

 

 

Description of work to be carried out by the partner(s) sought: 

Partner need to lead one WP and participate at least in two others

WP1 Management

WP2 Dissemination and communication.

WP4 Research and data collection.

Developing access to existed and establishing new medical data bases

WP3 Research the analysis methods and Modeling.

The medical data analysis methods and computational modeling.

WP4 System integration and software implementation.

WP5 Validation in pre-clinical and clinical studies.

WP6 System and methods demonstration. Demonstration to end users in 3 case studies.

WP7 Future research recommendations. The exploitation plan. 

Type of partner(s) sought: 

The consortium include:

1. Hospital/University experts in patient stratification aims at grouping patients into disease sub-groups, where the specific pathological processes involved are better defined (clinical/molecular phenotypes).

2. University/SME Developers of targeted therapies, optimizing the intervention to individual patients, achieving greater success in treating or curing the patient.

3. Hospital/University Researchers for disease-mechanism based patient stratification to address the needs for stratified or personalized therapeutic interventions.

4. University/Research Centers involving experts in pharmacogenomics or systems biomedicine approaches relevant for the objective above.

5. University/SME researchers experienced in the medical data analysis and computational modeling.

6. Hospitals or Clinique to be responsible for the new concepts validation in pre-clinical and clinical studies.

7. Patients associations connected to complex diseases having high prevalence.

8. Experts in the regulatory aspects of clinical practice and commercialization opportunities.

Looking for a Coordinator for your proposal: 
Yes

PROPOSER INFORMATION
Organisation: GARD Ltd
Department: R&D
Type of Organisation:
Industry - SME
Country:
Israel

PS ID: PS-IL-101558
Status: Closed
Date of last Modification: 16/11/2016
Date of Publication: 15/08/2016
Call Identifier: Other H2020 calls - looking for ICT expertise - WP 2016-17
Topic: Other H2020 calls - looking for ICT expertise - WP 2016-17
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Horizon 2020
Research and Innovation
Framework Programme

The Idealist2018 project is funded by the European Commission under the Leading Industrial Enabling Technologies ICT theme, of Horizon2020 – Research & Innovation Framework Programme, under grant agreement no. 645216. Any opinions expressed in these pages are those of the author/organisation and do not necessarily reflect the views of the European Commission.